H2N2V1, Main, Exploration, bibRecord, 000F77

Amino acid sequence analysis and identification of mutations under positive selection in hemagglutinin of 2009 influenza A (H1N1) isolates

Identifieur interne : 000F77 ( Main/Exploration ); précédent : 000F76; suivant : 000F78

Amino acid sequence analysis and identification of mutations under positive selection in hemagglutinin of 2009 influenza A (H1N1) isolates

Source :

Virus Genes [ 0920-8569 ] ; 2010-12-01.

RBID : ISTEX:E30A5250570A10A25DAEFF205FA4C70C8309B061

English descriptors

KwdEn :
- H1N1 influenza virus, Hemaglutinin, Mutation, Positive selection.

Abstract

Abstract: The 2009 flu pandemic is caused by a new strain of influenza A (H1N1) virus, A/H1N1/09. With its high transmissibility, this novel virus has caused a pandemic and infected over 600,000 people globally. By comparing the hemaglutinin (HA) gene and protein sequences among over 700 A/H1N1/09 isolates, mutations in the receptor-binding sites and antigenic epitope regions were identified. Among these mutations, T220 and E/G239 were found to be strongly positively selected over the course of spreading of the A/H1N1/09 virus worldwide. Interestingly, both sites are located in the highly variable epitope regions of HA1, and residue 239 also plays an important role in the receptor-binding process. Further analyses demonstrated that the percentage of T220 mutants among all isolates increased rapidly during the evolution, and that an E/G239 mutation could decrease the binding affinity of the virus with its cellular receptor. Thus, due to a potential functional importance of residues 220 and 239, mutations at these sites, as well as the significant of positive selection on these sites deserves more attention, while new vaccines and therapeutic drugs are developed against this novel virus.

Url:

https://api.istex.fr/ark:/67375/VQC-0F66MVDD-P/fulltext.pdf

DOI: 10.1007/s11262-010-0526-z

Affiliations:

Links toward previous steps (curation, corpus...)

to stream Istex, to step Corpus: 001393
to stream Istex, to step Curation: 001393
to stream Istex, to step Checkpoint: 000244
to stream Main, to step Merge: 000F85
to stream Main, to step Curation: 000F77

Le document en format XML

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<front><div type="abstract" xml:lang="en">Abstract: The 2009 flu pandemic is caused by a new strain of influenza A (H1N1) virus, A/H1N1/09. With its high transmissibility, this novel virus has caused a pandemic and infected over 600,000 people globally. By comparing the hemaglutinin (HA) gene and protein sequences among over 700 A/H1N1/09 isolates, mutations in the receptor-binding sites and antigenic epitope regions were identified. Among these mutations, T220 and E/G239 were found to be strongly positively selected over the course of spreading of the A/H1N1/09 virus worldwide. Interestingly, both sites are located in the highly variable epitope regions of HA1, and residue 239 also plays an important role in the receptor-binding process. Further analyses demonstrated that the percentage of T220 mutants among all isolates increased rapidly during the evolution, and that an E/G239 mutation could decrease the binding affinity of the virus with its cellular receptor. Thus, due to a potential functional importance of residues 220 and 239, mutations at these sites, as well as the significant of positive selection on these sites deserves more attention, while new vaccines and therapeutic drugs are developed against this novel virus.</div>
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<name sortKey="Huang, Ping" sort="Huang, Ping" uniqKey="Huang P" first="Ping" last="Huang">Ping Huang</name>
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<name sortKey="Jiang, Lifang" sort="Jiang, Lifang" uniqKey="Jiang L" first="Lifang" last="Jiang">Lifang Jiang</name>
<name sortKey="Jiang, Lifang" sort="Jiang, Lifang" uniqKey="Jiang L" first="Lifang" last="Jiang">Lifang Jiang</name>
<name sortKey="Ke, Changwen" sort="Ke, Changwen" uniqKey="Ke C" first="Changwen" last="Ke">Changwen Ke</name>
<name sortKey="Lei, Chunliang" sort="Lei, Chunliang" uniqKey="Lei C" first="Chunliang" last="Lei">Chunliang Lei</name>
<name sortKey="Li, Jun" sort="Li, Jun" uniqKey="Li J" first="Jun" last="Li">Jun Li</name>
<name sortKey="Li, Jun" sort="Li, Jun" uniqKey="Li J" first="Jun" last="Li">Jun Li</name>
<name sortKey="Li, Mengfeng" sort="Li, Mengfeng" uniqKey="Li M" first="Mengfeng" last="Li">Mengfeng Li</name>
<name sortKey="Li, Mengfeng" sort="Li, Mengfeng" uniqKey="Li M" first="Mengfeng" last="Li">Mengfeng Li</name>
<name sortKey="Li, Mengfeng" sort="Li, Mengfeng" uniqKey="Li M" first="Mengfeng" last="Li">Mengfeng Li</name>
<name sortKey="Liu, Liping" sort="Liu, Liping" uniqKey="Liu L" first="Liping" last="Liu">Liping Liu</name>
<name sortKey="Liu, Liping" sort="Liu, Liping" uniqKey="Liu L" first="Liping" last="Liu">Liping Liu</name>
<name sortKey="Tang, Xiaoping" sort="Tang, Xiaoping" uniqKey="Tang X" first="Xiaoping" last="Tang">Xiaoping Tang</name>
<name sortKey="Wu, Jueheng" sort="Wu, Jueheng" uniqKey="Wu J" first="Jueheng" last="Wu">Jueheng Wu</name>
<name sortKey="Wu, Jueheng" sort="Wu, Jueheng" uniqKey="Wu J" first="Jueheng" last="Wu">Jueheng Wu</name>
<name sortKey="Xu, Jun" sort="Xu, Jun" uniqKey="Xu J" first="Jun" last="Xu">Jun Xu</name>
<name sortKey="Xu, Lin" sort="Xu, Lin" uniqKey="Xu L" first="Lin" last="Xu">Lin Xu</name>
<name sortKey="Xu, Lin" sort="Xu, Lin" uniqKey="Xu L" first="Lin" last="Xu">Lin Xu</name>
<name sortKey="Yang, Xingfen" sort="Yang, Xingfen" uniqKey="Yang X" first="Xingfen" last="Yang">Xingfen Yang</name>
<name sortKey="Yang, Zhan" sort="Yang, Zhan" uniqKey="Yang Z" first="Zhan" last="Yang">Zhan Yang</name>
<name sortKey="Yuan, Jie" sort="Yuan, Jie" uniqKey="Yuan J" first="Jie" last="Yuan">Jie Yuan</name>
<name sortKey="Yuan, Jie" sort="Yuan, Jie" uniqKey="Yuan J" first="Jie" last="Yuan">Jie Yuan</name>
<name sortKey="Zhang, Yonghui" sort="Zhang, Yonghui" uniqKey="Zhang Y" first="Yonghui" last="Zhang">Yonghui Zhang</name>
<name sortKey="Zhu, Xun" sort="Zhu, Xun" uniqKey="Zhu X" first="Xun" last="Zhu">Xun Zhu</name>
<name sortKey="Zhu, Xun" sort="Zhu, Xun" uniqKey="Zhu X" first="Xun" last="Zhu">Xun Zhu</name>
</country>
</tree>
</affiliations>
</record>

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   |texte=   Amino acid sequence analysis and identification of mutations under positive selection in hemagglutinin of 2009 influenza A (H1N1) isolates
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Amino acid sequence analysis and identification of mutations under positive selection in hemagglutinin of 2009 influenza A (H1N1) isolates

Amino acid sequence analysis and identification of mutations under positive selection in hemagglutinin of 2009 influenza A (H1N1) isolates

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